Formation of lipid bilayers and vesicles using FMODPD

FCEWS and Dissipative Particle Dynamics (DPD) were used to simulate vesicle formation of the phospholipid POPC. FCEWS, developed by the Mochizuki Laboratory at Rikkyo University, segments lipid molecules and predicts interaction parameters (χ parameters) with high accuracy. The lipid fraction was then varied in DPD simulations to reproduce lipid bilayer and vesicle formation. Membrane area and thickness showed good agreement with experimental values, and the approach is expected to be applicable to drug delivery system (DDS) design.